Ages Eligible for Study: Birth to 1 Year (Child)

Sexes Eligible for Study: All

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Inclusion Criteria:

• Caregiver(s) must provide written or electronic consent after the nature of the study has been explained, and prior to any research-related procedures, per International Conference on Harmonisation (ICH) Good Clinical Practice (GCP).
• Subject must have a post-natal confirmed molecular genetic diagnosis of ENPP1 Deficiency with biallelic mutations (ie, homozygous or compound heterozygous) performed by a College of American Pathologists/Clinical Laboratory Improvement Amendments (CAP/CLIA) certified laboratory or equivalent.
• Subject must be male or female ages birth to <1 year of age at Baseline
• Subject must weigh ≥ 0.5 kg at the time of the first dose of INZ-701
• In the opinion of the Investigator, the subject must be able to complete all aspects of the study
• Subject's caregiver(s) must agree to provide access to their child's relevant medical records

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Exclusion Criteria:

• In the opinion of the Investigator, presence of any clinically significant disease or laboratory abnormality (outside of those considered associated with the diagnosis of ENPP1 Deficiency) that precludes study participation or may confound interpretation of study results, including known uncontrolled thyroid disease or unrelated connective tissue, bone, mineral, or muscle disease
• Care has been withdrawn or subject is receiving end of life care or hospice only
• Known malignancy
• Known intolerance to INZ-701 or any of its excipients
• Concurrent participation in another non-Inozyme interventional study and/or receipt of any other investigational new drug within 5 half-lives of the last dose of the other investigational product or from 4 weeks prior to the first dose of INZ-701, whichever is longer, or use of an investigational device, through completion of participation in the study